Maximum urine concentrating ability in children with Hb SC disease: Effects of hydroxyurea
نویسندگان
چکیده
منابع مشابه
Hydroxyurea decreases hospitalizations in pediatric patients with Hb SC and Hb SB+ thalassemia.
PURPOSE Patients with hemoglobin SC (Hb SC) and hemoglobin SB+ (Hb SB+) thalassemia suffer from frequent hospitalizations yet strong evidence of a clinical benefit of hydroxyurea (HU) in this population is lacking. Patients with recurrent hospitalizations for pain crisis are offered HU at our institution based on small cohort data and anecdotal benefit. This study identifies outcomes from a lar...
متن کاملNormal urine concentrating ability in magnesium depletion.
1. We studied urine concentrating ability in ten magnesium-depleted puppies and compared the results with those of match-fed, littermate controls. 2. The experimental puppies became hypomagnesaemic and hypocalcaemic without evidence of potassium depletion. After 24 h of food and water deprivation, urine osmolality increased to 1350k 340 mosm/kg of water. This value did not differ from that of c...
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Urine concentrating ability is reduced during normal aging in people and rats. The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats. The reductions in water, sodium, and urea transport protein abundances, and their reduced response to water restriction, contribute to the reduced ability of aged rats to c...
متن کاملThe xerocytosis of Hb SC disease.
Patients with Hb SC disease were found to have microcytic and hyperchromic red cell indices despite mild reticulocytosis. Iron deficiency anemia was ruled out by the finding of normal serum ferritin levels. In order to determine whether the microcytosis was due to coexistent alpha-thalassemia, restriction endonuclease mapping was performed on genomic DNA extracted from peripheral blood leukocyt...
متن کاملGlomerular filtration rate is altered in children with sickle cell disease: a comparison between Hb SS and Hb SC
BACKGROUND Renal failure is common among older patients with sickle cell disease; this is preceded by subclinical glomerular hyperfiltration. Data about renal function of adults with sickle cell disease have been reported, but data on children is scarce, especially when comparing heterozygotic and homozygotic patients. OBJECTIVE The goal of this study was to investigate the glomerular filtrat...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2000
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(200005)64:1<47::aid-ajh8>3.3.co;2-t